Central Effect of Some Vasoactive Substances as Observed by the Cross-circulation in the Dog.

cology, University of Tokyo. This series of experiments was originally designed to obtain informations on the role of chemical transmitters in the CNS. Though the essential role of adrenergic as well as cholinergic transmitters in the peripheral system is generally accepted, the role of these transmitter substances in the CNS is still obscure and requires further investigations to be elucidated. We had devised a newer method of cross-circulation of the head using dogs. The original idea and method were reported by J.F. and C. Heymans and coworkers in 1920.